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A US study has found that individuals who take drugs that suppress their immune systems, after having had an organ transplant, to stop the organ being rejected, are prone to be hampered in their ability to generate antibodies against Covid-19 after getting vaccinated. It has found that over half of the immunocompromised participants were not able to build antibodies even after receiving both vaccine doses. 

A person becomes vulnerable to Covid-19 when a the immune system is not able to generate a strong response against the deadly coronavirus. These people are known to be immunocompromised. There's a possibility that these people may not respond to Covid-19 vaccines also. 

The findings from another study say that immunosuppressed kidney transplant patients did respond somewhat to being given a dose of a Covid-19 vaccine, but that they had weaker antibody responses than those with fully functioning immune systems.

As per the reports by News18, a recent UK preprint (an early piece of research still awaiting review by other scientists) aimed to provide more information on how well the Pfizer/BioNTech and Oxford/AstraZeneca Covid-19 vaccines work in different at-risk groups. At risk groups include patients with diabetes, chronic heart disease, chronic kidney disease, chronic liver disease, neurological conditions as well as those who are immunocompromised. Most groups were able to generate strong antibody responses and they were found to be protected against symptomatic Covid-19 after being vaccinated. The study found that in the immunocompromised participants, antibody levels were lower after two doses, and after their first dose they were less well protected against symptomatic Covid-19 than the other groups. However, after being vaccinated with both doses, the immunocompromised group appeared to be well protected against the disease, even though their antibody levels were lower.